Journal
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
Volume 8, Issue 7, Pages 904-908Publisher
J INFECTION DEVELOPING COUNTRIES
DOI: 10.3855/jidc.3692
Keywords
Shigella; serodiversity; prevalence; antimicrobial resistance; diarrhea
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Funding
- National Key Program for Infectious Disease of China [2012ZX10004215-003-001]
- Project of Beijing High-Level Technical Personnel Training in Health [2013-3-099]
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Introduction: This study was conducted to determine the prevalence of serotypes, virulence factors, and antimicrobial resistance patterns of Shigella spp. in Beijing, China, from 2004 to 2011. Methodology: Real-time PCR assays were used to detect virulent genes, and the Kirby-Bauer disk diffusion method was used to evaluate antimicrobial resistance. Results: Among the total of 1,652 Shigella isolates, S. sonnei (57.1%) was the predominant species, followed by S. flexneri (42.3%), S. dysenteriae (0.4%), and S. boydii (0.2%). Nineteen serotypes were discovered among S. flexneri strains. The virulence gene ipaH was the most frequent, followed by sen and set. The presence of set showed significant difference in two dominant serogroups, S. flexneri and S. sonnei. Over 90% of Shigella isolates showed resistance to at least three drugs with widened spectrum. High-level antimicrobial resistance to single and multiple antibiotics was more common among S. sonnei than S. flexneri. Conclusion: There was an obvious serotype change and a dramatic increase of antibiotic resistance in Shigella prevalence in Beijing.
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