Journal
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
Volume 22, Issue 1, Pages 24-31Publisher
ELSEVIER
DOI: 10.1016/j.sjbs.2014.09.005
Keywords
Biomarkers; Polymerization; Sickle cell disease; Vaso-occlusion; Reticulocytes count; Hypercoagulability
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Sickle cell disease (SCD) is a hereditary blood disorder caused by a single gene. Various blood and urine biomarkers have been identified in SCD which are associated with laboratory and medical history. Biomarkers have been proven helpful in identifying different interconnected disease-causing mechanisms of SCD, including hypercoagulability, hemolysis, inflammation, oxidative stress, vasculopathy, reperfusion injury and reduced vasodilatory responses in endothelium, to name just a few. However, there exists a need to establish a panel of validated blood and urine biomarkers in SCD. This paper reviews the current contribution of biochemical markers associated with clinical manifestation and identification of sub-phenotypes in SCD. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.
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