Role of peroxisome proliferator-activated receptor gamma gene polymorphisms in type 2 diabetes mellitus patients of West Bengal, India

Aims/IntroductionPeroxisome proliferator activated receptor gamma (PPARG) is a nuclear hormone receptor of the ligand-dependent transcription factor involved in adipogenesis, and a molecular target of the insulin sensitizer, thiazolidinediones. The present study aimed to investigate whether the PPARG gene is associated with type 2 diabetes mellitus and its related traits within the population of West Bengal, India. Materials and MethodsThe study participants (200 type 2 diabetes mellitus and 200 normal individuals) were chosen randomly, and the variants were screened by direct sequencing. ResultsThe results showed that rs1801282 (odds ratio 0.66; 95% confidence interval 0.15-2.96; P=0.57) and rs3856806 (odds ratio 1.23; 95% confidence interval 0.73-2.06; P=0.44) variants of the PPARG gene were not associated with type 2 diabetes mellitus. ConclusionsThe results showed that the PPARG gene was not associated with type 2 diabetes mellitus in our study population. As the lack of association might come from the small sample size, further studies with larger sample size are required to verify the present observation.