4.3 Review

Molecular mechanisms involved in hepatic steatosis and insulin resistance

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

SREBPs: physiology and pathophysiology of the SREBP family

Hitoshi Shimano

FEBS JOURNAL (2009)

Article Biochemistry & Molecular Biology

Hepatic triacylglycerol accumulation and insulin resistance

Cynthia A. Nagle et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Endocrinology & Metabolism

Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women

Bettina Mittendorfer et al.

OBESITY (2009)

Article Gastroenterology & Hepatology

Gene expression in human NAFLD

Dario Greco et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Medicine, Research & Experimental

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

Catherine Postic et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Review Medicine, General & Internal

The epidemiology of obesity: the size of the problem

W. P. T. James

JOURNAL OF INTERNAL MEDICINE (2008)

Article Biochemistry & Molecular Biology

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

Kaori Minehira et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Biochemistry & Molecular Biology

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Takashi Matsuzaka et al.

NATURE MEDICINE (2007)

Article Biochemistry & Molecular Biology

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance

Cynthia A. Nagle et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

The nuclear receptor LXR is a glucose sensor

Nico Mitro et al.

NATURE (2007)

Review Physiology

Disordered lipid metabolism and the pathogenesis of insulin resistance

David B. Savage et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Endocrinology & Metabolism

Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice

Katsumi Iizuka et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)

Review Biochemistry & Molecular Biology

Signaling functions of phosphatidic acid

Xuemin Wang et al.

PROGRESS IN LIPID RESEARCH (2006)

Review Gastroenterology & Hepatology

Nonalcoholic fatty liver disease: From steatosis to cirrhosis

GC Farrell et al.

HEPATOLOGY (2006)

Review Endocrinology & Metabolism

Mechanisms of Disease: hepatic steatosis in type 2 diabetes - pathogenesis and clinical relevance

Michael Roden

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM (2006)

Article Gastroenterology & Hepatology

Acute hepatic steatosis in mice by blocking β-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production

A Grefhorst et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)

Article Biochemistry & Molecular Biology

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

DS Cai et al.

NATURE MEDICINE (2005)

Letter Cell Biology

SREBPs suppress IRS-2-mediated insulin signalling in the liver

T Ide et al.

NATURE CELL BIOLOGY (2004)

Article Multidisciplinary Sciences

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver

GX Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease

VT Samuel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

K Iizuka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Biochemistry & Molecular Biology

Lipotoxicity: when tissues overeat

JE Schaffer

CURRENT OPINION IN LIPIDOLOGY (2003)

Article Multidisciplinary Sciences

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

LL Listenberger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Identification of an intracellular receptor for lysophosphatidic acid (LPA):: LPA is a transcellular PPARγ agonist

TM McIntyre et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Endocrinology & Metabolism

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

SE Shoelson et al.

INTERNATIONAL JOURNAL OF OBESITY (2003)

Article Multidisciplinary Sciences

A central role for JNK in obesity and insulin resistance

J Hirosumi et al.

NATURE (2002)