Journal
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
Volume 2, Issue 4, Pages 250-255Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S2040174410000425
Keywords
cardiomyopathy; epigenetic; heart; PPAR; protein restriction
Categories
Funding
- British Heart Foundation [PG/06/098/21347]
Ask authors/readers for more resources
Impaired flexibility in the use of substrates for energy production in the heart is implicated in cardiomyopathy. We investigated the effect of maternal protein restriction during pregnancy in rats on the transcription of key genes in cardiac lipid and carbohydrate metabolism in the offspring. Rats were fed protein-sufficient or protein-restricted (PR) diets during pregnancy. Triacylglycerol concentration in adult (day 105) heart was altered by maternal protein intake contingent on post-weaning fat intake and sex. mRNA expression of peroxisomal proliferator-activated receptor (PPAR)-alpha and carnitine palmitoyltransferase-1 was increased by the maternal PR diet in adult, but not neonatal, offspring. PPAR alpha promoter methylation was lower in adult and neonatal heart from PR offspring. These findings suggest that prenatal nutrition alters the future transcriptional regulation of cardiac energy metabolism in the offspring through changes in epigenetic regulation of specific genes. However, changes in gene functional changes may not be apparent in early life.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available