4.3 Article

Lesional and circulating levels of interleukin-17 and 25-hydroxycholecalciferol in active acne vulgaris: Correlation to disease severity

Journal

JOURNAL OF COSMETIC DERMATOLOGY
Volume 18, Issue 2, Pages 671-676

Publisher

WILEY
DOI: 10.1111/jocd.12715

Keywords

25(OH)D3; acne; ELISA; IL-17; immunohistochemistry; Western blot

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ObjectivesThe immunological aspects of inflammatory acne are still incompletely understood, so this study aimed to investigate the possible role of IL-17 and 25 hydroxycholecalciferol (25(OH)D3) in the disease pathogenesis and progression. Materials and MethodsAcross-sectional study has been conducted on 135 patients with active acne vulgaris of various severities and 150 matched controls. ELISA assays of serum and tissue levels of IL-17 and 25(OH)D3, also immunohistochemical and Western blotting demonstration of the expression patterns of lesional IL-17 in comparison with control group, were performed. ResultsThe mean serum levels of IL-17 were 544.2pg/mL477.4 SD and 42.2pg/mL +/- 8.1 SD for acne patients and controls, respectively, with significantly higher levels among the patient group (P<0.05). Higher IL-17 expression levels in active acne lesions when compared with its level in healthy skin of the controls. The mean serum levels of 25(OH)D3 among patients and controls were 33.3ng/mL +/- 9.7 SD and 51.7ng/mL +/- 2.7 SD, respectively, with significantly lower levels among the patient group (P<0.05). There were significantly negative correlations between IL-17 and 25(OH)D3 levels (P<0.001 for both). ConclusionsDeficiency of vitamin D3 accompanied with higher IL-17 in an inverse pattern may have a possible role in active acne vulgaris.

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