Journal
PATHOGENS AND DISEASE
Volume 73, Issue 5, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftv016
Keywords
biofilm; nitroxide; ciprofloxacin
Categories
Funding
- Canadian Institutes for Health Research
- Cystic Fibrosis Canada
- Australian Research Council (ARC) Centre of Excellence for Free Radical Chemistry and Biotechnology [CE0561607]
- ARC Future Fellowship [FT140100746]
- Fundacion 'la Caixa'
- Fundacion Canada (Spain)
Ask authors/readers for more resources
We previously showed that soluble nitroxides (nitric oxide analogues) mimicked the well-established ability of nitric oxide to cause biofilm dispersal and further showed that these compounds could prevent biofilm formation. Here, we investigated the effect of the nitroxide carboxy-TEMPO in combination with sub mu g/ml concentrations of ciprofloxacin on pre-formed flow cell biofilms formed by Gram-negative bacteria. Combination therapy led to substantial eradication of existing biofilms formed by Pseudomonas aeruginosa PA14 (99.3%) and Escherichia coli O157 (93%).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available