Journal
INTERFACE FOCUS
Volume 2, Issue 3, Pages 278-291Publisher
ROYAL SOC
DOI: 10.1098/rsfs.2012.0016
Keywords
central neural tissue engineering; hyaluronic acid; central nervous system; regeneration; scaffold
Categories
Funding
- 973 programme [2011CB606205]
- National Natural Science Foundation of China [50973052, 50803031]
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Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engineering has attracted extensive attention from multi-disciplinary scientists in recent years, and many studies have been carried out to develop cell-and regeneration-activating biomaterial scaffolds that create an artificial micro-environment suitable for axonal regeneration. Among all the biomaterials, hyaluronic acid (HA) is a promising candidate for central neural tissue engineering because of its unique physico-chemical and biological properties. This review attempts to outline current biomaterials-based strategies for CNS regeneration from a tissue engineering point of view and discusses the main progresses in research of HA-based scaffolds for central neural tissue engineering in detail.
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