Journal
INTERFACE FOCUS
Volume 2, Issue 3, Pages 259-277Publisher
ROYAL SOC
DOI: 10.1098/rsfs.2012.0012
Keywords
bioceramics; protein adsorption; interface
Categories
Funding
- National High Technology Research and Development Programme of China [2011AA030105]
- National Natural Science Foundation of China [31170928]
- National 973 Programme [2011CB606201]
- Youth Scholar Fund [20090181120078]
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Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic-protein interactions.
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