Journal
INTERNATIONAL JOURNAL OF SURGERY
Volume 12, Issue 11, Pages 1216-1220Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijsu.2014.09.013
Keywords
ERCP; Complications; Coagulation screening; Cost effectiveness
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Introduction: Guidelines suggest that all patients with choledocholithiasis should have a coagulation screen prior to endoscopic retrograde cholangiopancreatography (ERCP). This study aims to establish the incidence of deranged coagulation in such patients and its relationship with bleeding complications. Methods: Analysis of consecutive patients undergoing ERCP procedures at two NHS sites was undertaken. Exclusion criteria were anti-coagulation use, bleeding disorders or incomplete data. Demographic data, pre-procedure bilirubin and prothrombin time (PT), ERCP procedural information, and bleeding complications were recorded for each. The cohort was divided into jaundice and non-jaundiced groups. Statistical analysis was performed using the student's t-test, Chi-squared test and Fisher's exact test. Results: 793 patients (419 jaundiced; 374 non-jaundiced) were included. PT was significantly higher in the jaundiced group (greater by 2 (1.35-2.64) seconds; p < 0.001). PT was prolonged in 26.7 per cent of the jaundiced group; 28 patients (6.7 per cent) had a PT of > 16.8 s 5.9 per cent of the non-jaundiced group had prolonged PT, with 1 patient having a PT > 16.8 s. There were 5 major, and 32 minor bleeding complications with no differences between groups. In those with abnormal coagulation, only 1 minor bleeding complication occurred in a jaundiced patient. Discussion: Normal pre-ERCP bilirubin was 99.7% (98.5-100) sensitive to predict a PT < 16.8 s. Cost savings of 14,350 pound could have been achieved with judicial use of coagulation screening. Conclusion: Pre-ERCP coagulation screening should only be indicated in patients with a raised bilirubin or individuals on anticoagulation therapy or with a history of bleeding diathesis. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
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