Journal
GUT PATHOGENS
Volume 3, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1757-4749-3-12
Keywords
aac(6 ')-Ib-cr; fluoroquinolones; plasmid-mediated resistance; Gram-negative
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Funding
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) [FIRB-Ideas RBID082ATK]
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The spread of aac(6')-Ib-cr plasmid-mediated quinolone resistance determinants was evaluated in 197 enterobacterial isolates recovered in an Italian teaching hospital. The aac(6')-Ib-cr gene was found exclusively in Escherichia coli strains. The gene was located on a plasmid which presented additional ESBL genes. Most of the clinical strains were clonally related and displayed three point mutations at the topoisomerase level which conferred high resistance to fluoroquinolones.
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