Journal
GREEN CHEMISTRY LETTERS AND REVIEWS
Volume 7, Issue 1, Pages 46-49Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17518253.2014.895858
Keywords
N; S-heterocyle; thiourea; ethyl 2-substituted-4-methylthiazole-5-carboxylates; cyclization
Funding
- Xi'an Jiaotong University Doctor Initiating Fund
- Fundamental Research Funds for the Central Universities
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, P. R. China
- National Natural Science Foundation of China [81172957]
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A new and practical one-pot procedure for the synthesis of several 2-sustituted-4-methylthiazole-5-carboxylates from commercially available starting materials is described. Under mild reaction conditions, some of the products with alkyl group on the 2-amino group or with various groups on 2-substituted phenyl ring were obtained in good yields from ethyl acetoacetate, N-bromosuccinimide, thiourea, or its N-substituted derivatives in an efficient way instead of the traditional two-step reaction.
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