4.5 Article

An efficient synthesis of alpha-hydroxyphosphonates and alpha-aminophosphonates in the presence of chlorotrimethylsilane

Journal

GREEN CHEMISTRY LETTERS AND REVIEWS
Volume 3, Issue 1, Pages 33-38

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/17518250903410082

Keywords

2-chloroquinoline-3-carbaldehyde; alpha-hydroxyphosphonate; imines; alpha-aminophosphonate; TMSCl

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Solvent free, and quantitative yielding synthesis of alpha-hydroxyphosphonates (2a-h) from 2-chloroquinolin-3-carbaldehyde (1a-h) and alpha-aminophosphonates (4a-p) from imines (3a-p), obtained from 2-chloroquinoline-3-carbaldehyde by using triethylphosphite in the presence of chlorotrimethylsilane at room temperature in short time. [GRAPHICS] .

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