Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 22, Issue 3, Pages 385-388Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458515595876
Keywords
Multiple sclerosis; pediatric; risk factors; Epstein-Barr virus; cytomegalovirus
Categories
Ask authors/readers for more resources
Epstein-Barr virus (EBV) infection is associated with increased multiple sclerosis (MS) risk. Recently, cytomegalovirus (CMV) infection has been proposed as a protective factor against MS development. We determined EBV, herpes simplex virus, varicella-zoster virus and CMV seroprevalence in 247 prospectively followed children with acquired demyelinating syndromes (ADS). Remote EBV infection was more common in children with MS than those with monophasic ADS while CMV infection was more common in children with monophasic ADS. Children displaying evidence of remote EBV without CMV infection were at highest risk of subsequent MS diagnosis. Viral infection repertoire detected at ADS provides important prognostic information.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available