Journal
DRUG DESIGN DEVELOPMENT AND THERAPY
Volume 8, Issue -, Pages 1979-1983Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S72129
Keywords
antimicrobial peptides; MRSA; lysostaphin; skin infection; mice
Categories
Funding
- Egyptian Cultural and Educational Bureau (ECEB) in Washington, DC, USA
Ask authors/readers for more resources
The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureus USA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available