Journal
CURRENT PSYCHIATRY REPORTS
Volume 13, Issue 2, Pages 138-146Publisher
SPRINGER
DOI: 10.1007/s11920-011-0184-4
Keywords
Alzheimer's disease; Genome-wide association study; Apolipoprotein E; Alzheimer's disease susceptibility genes
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Funding
- National Institutes of Health [R01-AG025259, R01-AG17173, R01-AG33193, U01-AG032984, P30-AG13846]
- anonymous private foundation
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Until recently, the search for genes contributing to Alzheimer's disease (AD) had been slow and disappointing, with the notable exception of the APOE epsilon 4 allele, which increases risk and reduces the age at onset of AD in a dose-dependent fashion. Findings from genome-wide association studies (GWAS) made up of fewer than several thousand cases and controls each have not been replicated. Efforts of several consortia-each assembling much larger datasets with sufficient power to detect loci conferring small changes in AD risk-have resulted in robust associations with many novel genes involved in multiple biological pathways. Complex data mining strategies are being used to identify additional members of these pathways and gene-gene interactions contributing to AD risk. Guided by GWAS results, next-generation sequencing and functional studies are under way with the hope of helping us better understand AD pathology and providing new drug targets.
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