Journal
CURRENT PSYCHIATRY REPORTS
Volume 13, Issue 2, Pages 147-155Publisher
SPRINGER
DOI: 10.1007/s11920-011-0176-4
Keywords
Genome-wide association study; GWAS; Addiction; Substance abuse; Alcohol; Smoking; Nicotine; Heroin; Methamphetamine
Categories
Funding
- German Federal Ministry of Education and Research (NGFN-Plus)
- Collaborative Research Center [SFB 636]
Ask authors/readers for more resources
Genome-wide association studies (GWAS) currently represent the most systematic approach to genetic research into complex disorders. They can detect associations of common variants in genomic regions in the absence of an a priori assumption. Most of the GWAS of addiction performed to date have focused on alcohol dependence or smoking behavior. Four GWAS of alcohol dependence have been published thus far, and only two single nucleotide polymorphisms have received modest support of replication in a subsequent study. Many more GWAS have been conducted for smoking behavior. One large, single GWAS and meta-analyses of the phenotype smoking quantity have generated convincing evidence for the contribution of variants in genes for cholinergic nicotinic receptor subunits. This article focuses on GWAS of alcohol addiction and provides an overview of GWAS of other substance abuse disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available