Journal
CURRENT PSYCHIATRY REPORTS
Volume 12, Issue 4, Pages 327-334Publisher
SPRINGER
DOI: 10.1007/s11920-010-0122-x
Keywords
Animal models; Schizophrenia; Psychosis; Antipsychotics
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Funding
- National Institute of Mental Health [MH070700, MH080910]
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Animal models are indispensible tools for advancing understanding of the cause of any given disease and developing new treatments. Developing animal models for schizophrenia presents formidable challenges owing to the distinctively human nature of the symptoms that define it and the thus-far-obscured underlying biological mechanisms. Nevertheless, progress has been and continues to be made in this important field of endeavor. This article discusses the challenges facing investigators who seek to develop and use animal models for translational research in schizophrenia and the responses that have emerged to those challenges, as well as the likely pathways that will lead to future progress.
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