Journal
CURRENT OPINION IN HIV AND AIDS
Volume 8, Issue 5, Pages 393-401Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/COH.0b013e328363d486
Keywords
ADCC; antibodies; HIV
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Funding
- NIAID NIH HHS [R01 AI094595] Funding Source: Medline
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Purpose of reviewAlthough a large number of novel broadly neutralizing antibodies has been recently described, the induction of such antibodies via vaccination has proven difficult. By contrast, nonneutralizing antibodies arise early during infection and have been repeatedly associated with both protection from infection and disease progression.Recent findingsWe are beginning to gain new insights into the broader landscape of antiviral mechanisms that nonneutralizing antibodies may harness to fight HIV, providing an unprecedented breadth of approaches by which HIV can be blocked and contained.SummaryIn this review, we summarize the characteristics of nonneutralizing antibodies, their role in HIV infection, and new paradigm-shifting functions that may be exploited by next-generation vaccine approaches aimed at blocking HIV infection.
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