Journal
CELL MOTILITY AND THE CYTOSKELETON
Volume 66, Issue 10, Pages 816-823Publisher
WILEY-LISS
DOI: 10.1002/cm.20353
Keywords
cytoskeleton; clathrin; entry; Listetia; septin
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Funding
- Canadian Institutes of Health Research
- Canadian Foundation
- Howard Hughes Medical Institute
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The study of an infection process can reveal how microbes exploit the host, and can illuminate unknown host cellular functions. Invasive pathogens have evolved efficient strategies to promote their internalization within normally non-phagocytic host cells. The so-called zippering bacteria present to host cell receptors molecules that mimic endogenous ligands, thereby inducing specific intracellular signaling cascades ultimately resulting in actin polymerization and uptake. Here we review how the bacterial pathogen Listeria monocytogenes enters into cells, and present a series of studies revealing that in addition to actin rearrangements this bacterium exploits the clathrin-mediated endocytosis machinery together with septins, a novel cytoskeleton element. The challenge is now to decipher how all of these components orchestrate themselves to permit entry into normally non-phagocytic cells. Cell Motil. Cytoskeleton 66: 816-823, 2009. (C) 2009 Wiley-Liss, Inc.
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