Journal
CELL ADHESION & MIGRATION
Volume 8, Issue 6, Pages 578-587Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/19336918.2014.972740
Keywords
breast cancer; cellular plasticity; differentiation; EMT; mammary stem cells; SLUG
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Funding
- NICHD NIH HHS [R01 HD073035] Funding Source: Medline
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SLUG, a member of the SNAIL family of transcriptional repressors, is known to play a diverse number of roles in the cell, and its deregulation has been observed in a variety of cancers including breast. Here, we focus on SLUG's role as a master regulator of mammary epithelial cell (MEC) fate and lineage commitment in the normal mammary gland, and discuss how aberrant SLUG expression can influence breast tumor formation, phenotype, and progression. Specifically, we discuss SLUG's involvement in MEC differentiation, stemness, cellular plasticity, and the epithelial to mesenchymal transition (EMT), and highlight the complex connection between these programs during development and disease progression. Undoubtedly, delineating how molecular factors influence lineage identity and cell-state dynamics in the normal mammary gland will contribute to our understanding of breast tumor heterogeneity.
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