Journal
CELL ADHESION & MIGRATION
Volume 7, Issue 1, Pages 48-55Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22826
Keywords
laminin; laminin-type epidermal growth factor-like (LE) domain; laminin N-terminal (LN) domain; coil-coiled domain; adhesion; integrin
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Funding
- German Federal Ministry for Education and Research (Network Epidermolysis bullosa) [01GM0832]
- German Federal Ministry for Education and Research (Network Stem Cell Therapy for Severe Skin Fragility Syndromes) [01GN0972]
- Marga und Boll Stiftung
- Koln Fortune program from the Medical Faculty of the University of Cologne
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Laminins are large molecular weight glycoproteins constituted by the assembly of three disulfide-linked polypeptides, the alpha, beta and gamma chains. The human genome encodes 11 genetically distinct laminin chains. Structurally, laminin chains differ by the number, size and organization of a few constitutive domains, endowing the various members of the laminin family with common and unique important functions. In particular, laminins are indispensable building blocks for cellular networks physically bridging the intracellular and extracellular compartments and relaying signals critical for cellular behavior, and for extracellular polymers determining the architecture and the physiology of basement membranes.
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