Journal
CELL ADHESION & MIGRATION
Volume 7, Issue 1, Pages 150-159Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22827
Keywords
laminin-111; synthetic peptide; metastasis; tumor growth; angiogenesis; migration; adhesion; basement membrane; proteases
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Funding
- Grants-in-Aid for Scientific Research [23501270, 24500530, 24390304, 22390017] Funding Source: KAKEN
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Laminin-111 is a large trimeric basement membrane glycoprotein with many active sites. In particular, four peptides active in tumor malignancy studies have been identified in laminin-111 using a systematic peptide screening method followed by various assays. Two of the peptides (IKVAV and AG73) are found on the alpha 1 chain, one (YIGSR) of the beta 1 chain and one (C16) on the gamma 1 chain. The four peptides have distinct activities and receptors. Since three of the peptides (IKVAV, AG73 and C16) strongly promote tumor growth, this may explain the potent effects laminin-111 has on malignant cells. The peptide, YIGSR, decreases tumor growth and experimental metastasis via a 32/67 kD receptor while IKVAV increases tumor growth, angiogenesis and protease activity via integrin receptors. AG73 increases tumor growth and metastases via syndecan receptors. C16 increases tumor growth and angiogenesis via integrins. Identification of such sites on laminin-111 will have use in defining strategies to develop therapeutics for cancer.
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