Journal
CELL ADHESION & MIGRATION
Volume 7, Issue 1, Pages 122-134Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.23132
Keywords
laminin 332; LG45 domain; LE domain; syndecan; basement membrane; keratinocyte
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Funding
- Agence Nationale pour la Recherche grants Chemispike and adhesioMab
- Association pour la Recherche sur le Cancer
- Ligue Nationale contre le Cancer
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Laminin 332, composed of the alpha 3, beta 3 and gamma 2 chains, is an epithelial-basement membrane specific laminin variant. Its main role in normal tissues is the maintenance of epithelial-mesenchymal cohesion in tissues exposed to external forces, including skin and stratified squamous mucosa. After being secreted and deposited in the extracellular matrix, laminin 332 undergoes physiological maturation processes consisting in the proteolytic processing of domains located within the alpha 3 and the gamma 2 chains. These maturation events are essential for laminin 332 integration into the basement membrane where it plays an important function in the nucleation and maintenance of anchoring structures. Studies in normal and pathological situations have revealed that laminin 332 can trigger distinct cellular events depending on the level of its proteolytic cleavages. In this review, the biological and structural characteristics of laminin 332 domains are presented and we discuss whether they trigger specific functions.
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