Journal
CELL ADHESION & MIGRATION
Volume 7, Issue 5, Pages 418-423Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.26375
Keywords
PTP1B; integrins; adhesions; migration; endoplasmic reticulum; alpha-actinin; Src; cytoskeleton
Categories
Funding
- Agencia Nacional para la Promocion Cientifica y Tecnologica (ANPCYT)
- Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)
- ANPCYT [PICTs 1363, 2129]
Ask authors/readers for more resources
Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support cell movement. The endoplasmic reticulum-bound protein tyrosine phosphatase PTP1B has been implicated as a regulator of cell adhesion and migration. Recent results from our laboratory shed light on potential mechanisms, such as Src/FAK signaling through Rho GTPases and integrin-cytoskeletal coupling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available