Journal
CELL ADHESION & MIGRATION
Volume 6, Issue 6, Pages 535-540Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22243
Keywords
VEGF; urokinase; urokinase receptor; integrin; migration; endothelial cells; angiogenesis
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Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator system, consisting of the urokinase-type plasminogen activator (uPA), its cellular receptor uPAR and its inhibitor PAI-1, participates in the realization of these VEGF-induced processes by activating pericellular proteolysis, increasing vascular permeability and by supporting endothelial cell proliferation and migration.
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