Journal
CELL ADHESION & MIGRATION
Volume 6, Issue 1, Pages 59-70Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.19583
Keywords
CAMs; hESCs; hiPSCs; self-renewal; pluoripotency; E-cadherin; integrins; IgSF CAMs; HSPGs
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [MOP-111224, MSH-166732, MOP 62826]
- Ontario Government
Ask authors/readers for more resources
The survival, proliferation, self-renewal and differentiation of human pluripotent stem cells (hPSCs, including human embryonic stem cells and human induced pluripotent stem cells) involve a number of processes that require cell-cell and cell-matrix interactions. The cell adhesion molecules (CAMs), a group of cell surface proteins play a pivotal role in mediating such interactions. Recent studies have provided insights into the essential roles and mechanisms of CAMs in the regulation of hPSC fate decisions. Here, we review the latest research progress in this field and focus on how E-cadherin and several other important CAMs including classic cadherins, Ig-superfamily CAMs, integrins and heparin sulfate proteoglycans control survival and differentiation of hPSCs
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available