Journal
CELL ADHESION & MIGRATION
Volume 6, Issue 6, Pages 554-560Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22419
Keywords
VEGF; neuropilin; integrin; cancer
Categories
Funding
- NIH [CA168464]
- DOD Prostate Cancer Grant [PC111410]
- CDMRP [PC111410, 546898] Funding Source: Federal RePORTER
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This review advances the hypothesis that the ability of integrins to engage their extracellular matrix ligands and signal can be regulated in tumor cells by vascular endothelial growth factor (VEGF), a major angiogenic factor that also has direct effects on the function of tumor cells. More specifically, we will discuss how neuropilins (NRPs), a distinct class of VEGF receptors, enable the function of specific integrins that contribute to tumor initiation and progression.
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