Journal
CELL ADHESION & MIGRATION
Volume 6, Issue 3, Pages 203-219Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.20377
Keywords
fibrosis; wound healing; transforming growth factor-beta; extracellular matrix; mechanosensing
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro
- Canadian Institutes of Health Research grants [210820, 219974]
- Collaborative Health Research Programme NSERC/CIHR grant [1004005]
- Heart and Stroke Foundation Ontario grant [NA7086]
- Swiss National Science Foundation grant [3200-067254]
- University of Limoges
- French Ministry of Research
Ask authors/readers for more resources
Since its first description in wound granulation tissue, the myofibroblast has been recognized to be a key actor in the epithelial-mesenchymal cross-talk that plays a crucial role in many physiological and pathological situations, such as regulation of prostate development, ventilation-perfusion in lung alveoli or organ fibrosis. The presence of myofibroblasts in the stroma reaction to epithelial tumors is well established and many data are accumulating which suggest that the stroma compartment is an active participant in tumor onset and/or evolution. In this review we summarize the evidence in favor of this concept, the main mechanisms that regulate myofibroblast differentiation and function, as well as the biophysical and biochemical factors possibly involved in epithelial- stroma interactions, using liver carcinoma as main model, in view of achieving a better understanding of tumor progression mechanisms and of tools directed toward stroma as eventual therapeutic target.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available