Journal
CELL ADHESION & MIGRATION
Volume 4, Issue 4, Pages 609-621Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.4.4.13489
Keywords
cardiac neural crest; migration; signaling; matrix; pharyngeal arches; rhombencephalic streams
Categories
Funding
- [HL036059]
- [HL070140]
- [HL083240]
- [AHA0830464N]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL083240, P01HL036059, R01HL070140] Funding Source: NIH RePORTER
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Cardiac neural crest cells originate as part of the postotic caudal rhombencephalic neural crest stream. Ectomesenchymal cells in this stream migrate to the circumpharyngeal ridge and then into the caudal pharyngeal arches where they condense to form first a sheath and then the smooth muscle tunics of the persisting pharyngeal arch arteries. A subset of the cells continues migrating into the cardiac outflow tract where they will condense to form the aorticopulmonary septum. Cell signaling, extracellular matrix and cell-cell contacts are all critical for the initial migration, pauses, continued migration and condensation of these cells. This Review elucidates what is currently known about these factors.
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