Journal
CELL ADHESION & MIGRATION
Volume 4, Issue 1, Pages 1-3Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.4.1.9914
Keywords
cell migration; neural progenitor cells (NPCs); rostral migratory stream (RMS); sonic hedgehog (Shh); subventricular zone (SVZ)
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The developmental morphogen Sonic hedgehog (Shh) is well known for its role in modulating the proliferation and survival of neural progenitor cells in the developing mouse brain. A recent report now showed that Shh could regulate the migration of neuroblast in the adult subventricular zone (SVZ) along the rostral migratory stream (RMS) to the olfactory bulb, by functioning as a chemoattractant. Functions of Shh in regulating the migration and survival of neural progenitor cells in the adult central nervous system are suggestive of its potential roles in neural regeneration and CNS oncogenesis.
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