Journal
CELL ADHESION & MIGRATION
Volume 4, Issue 2, Pages 235-240Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.4.2.11404
Keywords
migration; proliferation; multipotent mesenchymal stromal cells; chemokines; demyelination
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Funding
- The Ipsen Trust
- The Patrick Berthoud Charitable Foundation
- The Burden Trust
- National Institute for Health Research [CL-2010-25-003] Funding Source: researchfish
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Systemic delivery of multipotent mesenchymal stem cells (MSC) may be of benefit in the treatment of neurological diseases, including multiple sclerosis (MS). Certainly, animal studies have demonstrated functional benefits following MSC transplantation, although the mechanisms by which MSCs migrate to lesions and stimulate repair remain unknown. Chemokines stimulate migration in other settings. In this study, we systematically explore the migratory and proliferative responses of human MSCs (hMSC) to chemokines expressed in MS lesions. We demonstrate that these chemokines trigger hMSC migration. In addition, we show that RANTES and IP-10 promote hMSC proliferation.
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