Journal
CELL ADHESION & MIGRATION
Volume 4, Issue 2, Pages 169-171Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cam.4.2.11716
Keywords
ovarian cancer; cell survival; MAGP2; alpha(v)beta(3); endothelial cell
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Ovarian cancer is the most lethal gynecologic cancer, and this is largely related to its late diagnosis. High grade serous cancers often initially respond to chemotherapy, resulting in a better survival rate, compared to other ovarian carcinoma subtypes. We review recent work identifying a survival-associated gene expression profile for advanced serous ovarian cancer. Within this signature, the authors identified MAGP2, also known as microfibrillar associated protein 5 (MFAP5), as a highly significant indicator of survival and chemosensitivity. MAGP2 is a multifunctional secreted protein-important for elastic microfibril assembly and modulating endothelial cell behavior-with a newly identified role in cell survival. Through alpha(v)beta(3) integrin-mediated signaling, MAGP2 promotes tumor and endothelial cell survival and endothelial cell motility, providing a potential mechanistic link between MAGP2 and angiogenesis as well as patient survival.
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