Journal
CELL ADHESION & MIGRATION
Volume 3, Issue 2, Pages 205-210Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.3.2.7855
Keywords
angiogenesis; blood vessel; brain; CNS; embryo; endothelial cell; neural crest; neural tube; pattern formation; pericyte; spinal cord
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First steps of blood vessel formation and patterning in the central nervous system (CNS) of higher vertebrates are presented. Corresponding to the regional diversity of the embryonic CNS (unsegmented spinal cord vs segmented brain anlagen) and its surroundings (segmented trunk vs unsegmented head mesoderm, neural crest-derived mesenchyme), cells of different origins contribute to the endothelial and mural cell populations. The autonomous migratory potential of endothelial cells is guided by attractive and repulsive clues. Nevertheless, a common pattern in both spinal cord and forebrain vascularization appears, with primary ventral vascular sprouts supplying the periventricular vascular plexus of the neural tube, whereas dorsolateral sprouts appear later.
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