Journal
CELL ADHESION & MIGRATION
Volume 2, Issue 3, Pages 161-166Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.2.3.6549
Keywords
desmosome; cell-cell adhesion; intercellular junction; tyrosine phosphorylation; pervanadate; desmoglein; plakoglobin
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Funding
- Medical Research Council
- Medical Research Council [G9630879] Funding Source: researchfish
- MRC [G9630879] Funding Source: UKRI
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Desmosomes are intercellular junctions responsible for strong cell-cell adhesion in epithelia and cardiac muscle. Numerous studies have shown that the other major type of epithelial cell adhesion, the adherens junction, is destabilized by src-induced tyrosine phosphorylation of two of its principal components, E-cadherin and beta-catenin. Here we show that treatment of epithelial cells with the potent tyrosine phosphatase inhibitor sodium pervanadate causes tyrosine phosphorylation of the major desmosomal components desmoglein 2 and plakoglobin in both the non-ionic detergent soluble and insoluble cell fractions and, surprisingly, stabilizes desmosomal adhesion, inducing the hyper-adhesive form normally found in tissues and confluent cell sheets. Taken together with the few other studies on desmosomes these results suggest that the effects of tyrosine phosphorylation on desmosomal adhesion are complex.
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