Journal
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 107, Issue 11, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/djv219
Keywords
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Categories
Funding
- US National Institutes of Health (NIH) [R37CA070867]
- Ingram Professorship endowment
- Anne Potter Wilson endowment
- European Community's Seventh Framework Programme [223175, HEALTH-F2-2009-223175]
- European Community's Seventh Framework Programme (COGS) [223175 (HEALTH-F2-2009-223175)]
- Cancer Research UK (CR-UK) [C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692]
- National Institutes of Health [CA128978, R01 CA77398]
- Post-Cancer GWAS initiative (GAME-ON initiative) [1U19 CA148537, 1U19 CA148065, 1U19 CA148112]
- Department of Defence [W81XWH-10-1-0341]
- Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer
- Komen Foundation for the Cure
- Breast Cancer Research Foundation
- Ovarian Cancer Research Fund
- National Cancer Institute (NCI) [U19 CA148065]
- National Cancer Institute [UM1 CA164920]
- National Health and Medical Research Council of Australia
- New South Wales Cancer Council
- Victorian Health Promotion Foundation (Australia)
- Victorian Breast Cancer Research Consortium
- Dutch Cancer Society [NKI 2007-3839, 2009 4363, RUL 1997-1505, DDHK 2004-3124, DDHK 2009-4318]
- BBMRI-NL - Dutch government [NWO 184.021.007]
- Dutch National Genomics Initiative
- ELAN-Fond of the University Hospital of Erlangen
- Breakthrough Breast Cancer
- National Health Service (NHS)
- CR-UK [C1287/A10118, C1287/A12014]
- European Union European Cooperation in Science and Technology (COST) programme [BM0606]
- NIHR Comprehensive Biomedical Research Centre
- Guy's & St. Thomas' NHS Foundation Trust
- King's College London, United Kingdom
- Oxford Biomedical Research Centre
- Dietmar-Hopp Foundation
- Helmholtz Society
- German Cancer Research Center (DKFZ)
- Fondation de France
- Institut National du Cancer (INCa)
- Ligue Nationale contre le Cancer
- Ligue contre le Cancer Grand Ouest
- Agence Nationale de Securite Sanitaire (ANSES)
- Agence Nationale de la Recherche (ANR)
- Chief Physician Johan Boserup and Lise Boserup Fund
- Danish Medical Research Council
- Herlev Hospital
- Genome Spain Foundation
- Red Tematica de Investigacion Cooperativa en Cancer
- Asociacion Espanola Contra el Cancer
- Fondo de Investigacion Sanitario [PI11/00923, PI081120]
- Instituto de Salud Carlos III
- California Breast Cancer Act of 1993
- California Breast Cancer Research Fund [97-10500]
- Lon V Smith Foundation [LVS39420]
- Baden Wurttemberg Ministry of Science, Research and Arts
- German Cancer Aid (Deutsche Krebshilfe)
- Deutsche Krebshilfe [107 352]
- Federal Ministry of Education and Research (BMBF) Germany [01KW9975/5, 01KW9976/8, 01KW9977/0, 01KW0114, 01KH0402]
- Robert Bosch Foundation, Stuttgart
- Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
- Department of Internal Medicine
- Evangelische Kliniken Bonn gGmbH
- Johanniter Krankenhaus, Bonn, Germany
- Helsinki University Central Hospital Research Fund
- Academy of Finland [266528]
- Finnish Cancer Society
- Nordic Cancer Union
- Sigrid Juselius Foundation
- Friends of Hannover Medical School
- Rudolf Bartling Foundation
- Stockholm County Council
- Karolinska Institutet
- Swedish Cancer Society
- Gustav V Jubilee Foundation
- Bert von Kantzows Foundation
- special Government Funding (EVO) of Kuopio University Hospital grants
- Cancer Fund of North Savo
- Finnish Cancer Organizations
- University of Eastern Finland
- National Breast Cancer Foundation
- National Health and NHMRC
- Queensland Cancer Fund
- Cancer Council of New South Wales
- Cancer Council of Victoria
- Cancer Council of Tasmania
- Cancer Council of South Australia
- Cancer Foundation of Western Australia
- NHMRC [145684, 288704, 454508, 199600]
- United States Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- Cancer Council of Tasmania and Cancer Foundation of Western Australia
- Stichting tegen Kanker [232-2008, 196-2010]
- Flemish Fund for Scientific Research
- KULPFV/10/016-SymBioSysII
- Deutsche Krebshilfe e.V. [70-2892-BR I, 106332, 108253, 10841]
- Hamburg Cancer Society
- German Cancer Research Center
- Italian Association for Cancer Research (AIRC)
- Fondazione IRCCS Istituto Nazionale Tumori
- NIH [CA128978, CA116167, CA176785, CA63464, CA54281, CA098758, CA132839]
- NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201]
- VicHealth
- Cancer Council Victoria
- Australian NHMRC [209057, 251553, 504711]
- Quebec Breast Cancer Foundation
- Canadian Institutes of Health Research for the CIHR Team in Familial Risks of Breast Cancer program [CRN-87521]
- Ministry of Economic Development, Innovation and Export Trade [PSR-SIIRI-701]
- Norwegian Research council [155218/V40, 175240/S10]
- FUGE-NFR [181600/V11]
- Swizz Bridge Award
- Finnish Cancer Foundation
- Academy of Finland
- University of Oulu
- Oulu University Hospital
- Biobanking and Biomolecular Resources Research Infrastructure [BBMRI-NL CP16]
- Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services
- Marit and Hans Rausings Initiative Against Breast Cancer
- Agency for Science, Technology and Research of Singapore (A*STAR)
- US National Institute of Health
- Susan G. Komen Breast Cancer Foundation
- Yorkshire Cancer Research [S295, S299, S305PA]
- UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge
- Cancer Research UK [C490/A10124]
- DKFZ
- Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201]
- Hellenic Cooperative Oncology Group research grant [HR R_BG/04]
- Stefanie Spielman Breast Cancer fund
- OSU Comprehensive Cancer Center
- DBBR (a CCSG Share Resource by National Institutes of Health) [P30 CA016056]
- Greek General Secretary for Research and Technology (GSRT) Program
- Research Excellence II
- European Union (European Social Fund)
- Greek national funds through the Operational Program Education and Lifelong Learning of the National Strategic Reference Framework (NSRF), ARISTEIA
- Institute of Cancer Research (ICR)
- NHS
- [PBZ_KBN_122/P05/2004]
- British Heart Foundation [RG/08/014/24067] Funding Source: researchfish
- Cancer Foundation Finland sr [130168] Funding Source: researchfish
- Cancer Research UK [16565, 16561, 16563, 16459] Funding Source: researchfish
- Cancer Research UK
- The Francis Crick Institute [10124] Funding Source: researchfish
- Medical Research Council [MR/L003120/1] Funding Source: researchfish
- National Institute for Health Research [03/DHCS/03/G121/51, NF-SI-0512-10165] Funding Source: researchfish
- MRC [MR/L003120/1] Funding Source: UKRI
Ask authors/readers for more resources
Background: Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear. Methods: We performed a meta-analysis to investigate associations between height and breast cancer risk using data from 159 prospective cohorts totaling 5 216 302 women, including 113 178 events. In a consortium with individual-level data from 46 325 case patients and 42 482 control subjects, we conducted a Mendelian randomization analysis using a genetic score that comprised 168 height-associated variants as an instrument. This association was further evaluated in a second consortium using summary statistics data from 16 003 case patients and 41 335 control subjects. Results: The pooled relative risk of breast cancer was 1.17 (95% confidence interval [CI] = 1.15 to 1.19) per 10 cm increase in height in the meta-analysis of prospective studies. In Mendelian randomization analysis, the odds ratio of breast cancer per 10 cm increase in genetically predicted height was 1.22 (95% CI = 1.13 to 1.32) in the first consortium and 1.21 (95% CI = 1.05 to 1.39) in the second consortium. The association was found in both premenopausal and postmenopausal women but restricted to hormone receptor-positive breast cancer. Analyses of height-associated variants identified eight new loci associated with breast cancer risk after adjusting for multiple comparisons, including three loci at 1q21.2, DNAJC27, and CCDC91 at genome-wide significance level P < 5 x 10(-8). Conclusions: Our study provides strong evidence that adult height is a risk factor for breast cancer in women and certain genetic factors and biological pathways affecting adult height have an important role in the etiology of breast cancer.
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