Journal
CANCER GENETICS
Volume 228, Issue -, Pages 41-46Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergen.2018.08.002
Keywords
Myeloproliferative neoplasm; ABL1-ETV6 rearrangement; Tyrosine kinase inhibitors
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Myeloproliferative neoplasms (MPN) associated with ABL1-ETV6 fusions are rare and poorly characterized. To date, less than 20 cases of ABL1-ETV6+ MPN have been reported. We report a 47-year-old man who presented with MPN with clinicopathologic features resembling chronic myeloid leukemia, but there was no evidence of t(9;22)(p34.1;q11.2) or BCR-ABL1 fusion. Conventional cytogenetics and fluorescence in situ hybridization analysis showed ins(12;9)(p13;q34q34) that led to ETV6-ABL1 fusion. The patient responded well to tyrosine kinase inhibitor therapy and achieved remission for 7 years.
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