Journal
CANCER GENETICS
Volume 204, Issue 3, Pages 147-152Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergen.2011.01.003
Keywords
Acute lymphoblastic leukemia; fusion gene; TAF15-ZNF384
Categories
Funding
- Norwegian Cancer Society
- Southeastern Norway Regional Health Authority
Ask authors/readers for more resources
We report the clinical, cytogenetic, and molecular data of two patients diagnosed with acute lymphoblastic leukemia characterized by the rare translocation t(12;17)(p13;q12). This translocation has been reported in 25 cases and its putative molecular consequence, the formation of a TAF15-ZNF384 fusion gene, in only six cases. We used fluorescence in situ hybridization followed by long-range polymerase chain reaction to find the translocation breakpoints. A fusion between TAF15 and ZNF384 was identified and confirmed by nucleotide sequencing. Our results confirm that the t(12;17)(p13;q12) leading to a TAF15 ZNF384 fusion gene characterizes a specific subgroup of acute lymphoblastic leukemia and suggest that two different breakpoints in TAF15 may be involved. Whether the two variants of the TAF15 ZNF384 fusion that these correspond to are in any way hematologically or prognostically different, is unknown.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available