Journal
CANCER DISCOVERY
Volume 4, Issue 6, Pages 642-645Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-14-0409
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Funding
- Cancer Research UK [C309/A8274]
- Cancer Research UK
- National Institute of Health Research (NIHR)
- Department of Health
- Cancer Research UK [11566] Funding Source: researchfish
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The crystal structure of a conserved tubulin-binding region of the EML1 protein reveals a highly atypical fold in one of its beta-propeller domains. Disruption of the EML1 core region domain in many of the oncogenic EML4-ALK fusion protein variants that drive non-small cell lung cancer explains their dependence on the HSP90 molecular chaperone, provides a basis to allow more precise patient stratification for therapy, and suggests a more general model for other oncogenic fusion proteins. (C) 2014 AACR.
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