Journal
CANCER DISCOVERY
Volume 3, Issue 1, Pages 35-43Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-12-0361
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Funding
- PHS awards [R01CA113794, U01-1156106]
- Stand Up To Cancer Innovative Research Grant
- Program of the Entertainment Industry Foundation [SU2C-AACR-IRG0309]
- Cure AT/RT Now Foundation
- Garrett B. Smith Foundation
- St. Baldrick's Foundation
- Alex's Lemonade Stand Foundation
- William Lawrence and Blanche Hughes Foundation
- Boston Children's Hospital
- NATIONAL CANCER INSTITUTE [R01CA113794, U01CA105423] Funding Source: NIH RePORTER
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Although disordered chromatin organization has long been recognized as a feature of cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their relationships to transcription are only beginning to be understood. Cancer genome sequencing studies have revealed a novel theme: frequent mutation of epigenetic regulators. Among these, the ARID1A/BAF250A subunit of the SWI/SNF (BRG1-associated factors) chromatin remodeling complex has emerged as recurrently mutated in a broad array of tumor types. We review the genomic and functional data supporting classification of ARID1A as a tumor suppressor.
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