Journal
CANCER DISCOVERY
Volume 2, Issue 12, Pages 1078-1080Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-12-0465
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Funding
- NCI NIH HHS [R01 CA129523, R01 CA057621] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007618] Funding Source: Medline
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Mitra and colleagues analyzed microRNA expression profiles of fibroblasts isolated from ovarian cancer patients, searching for dysregulated microRNAs in the stromal compartment of human cancer. They found that decreased miR-31 and miR-214 and increased miR-155 expression can reprogram normal fibroblasts into tumor-promoting cancer-associated fibroblasts. They identified CCL5, a protumorigenic chemokine that is highly expressed in tumors, as a key target of miR-214, thus showing that microRNA perturbation in the stromal microenvironment can affect tumor growth. Cancer Discov; 2(12); 1078-80. (C) 2012 AACR.
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