Journal
CANCER DISCOVERY
Volume 1, Issue 5, Pages 391-407Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-11-0209
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Funding
- Department of Defense [PC100171, PC094290]
- NIH [P50CA69568]
- NIH Early Detection Research Network [U01 CA 11275]
- Doris Duke Charitable Foundation
- Burroughs Welcome Foundation
- Prostate Cancer Foundation
- American Cancer Society
- Howard Hughes Medical Institute
- University of Michigan
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The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to mammals has dramatically altered our understanding of cell biology, especially the biology of diseases such as cancer. In humans, the identification of abundant long ncRNA (lncRNA) >200 bp has catalyzed their characterization as critical components of cancer biology. Recently, roles for lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types, such as breast and prostate cancer. In this review, we highlight the emerging impact of ncRNAs in cancer research, with a particular focus on the mechanisms and functions of lncRNAs. Significance: lncRNAs represent the leading edge of cancer research. Their identity, function, and dysregulation in cancer are only beginning to be understood, and recent data suggest that they may serve as master drivers of carcinogenesis. Increased research on these RNAs will lead to a greater understanding of cancer cell function and may lead to novel clinical applications in oncology. Cancer Discovery;1(5):391-407. (C) 2011 AACR.
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