Journal
JAMA PEDIATRICS
Volume 169, Issue 10, Pages 956-963Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/jamapediatrics.2015.1387
Keywords
-
Categories
Funding
- NHLBI NIH HHS [T32 HL076139, P01 HL071643, R01 HL079190, R01 HL124664] Funding Source: Medline
Ask authors/readers for more resources
Infection with influenza A virus is responsible for considerable morbidity and mortality in children worldwide. While it is apparent that adequate activation of the innate immune system is essential for pathogen clearance and host survival, an excessive inflammatory response to infection is detrimental to the young host. A review of the literature indicates that innate immune responses change throughout childhood. Whether these changes are genetically programmed or triggered by environmental cues is unknown. The objectives of this review are to summarize the role of innate immunity in influenza A virus infection in the young child and to highlight possible differences between children and adults that may make children more susceptible to severe influenza A infection. A better understanding of age-related differences in innate immune signaling will be essential to improve care for this high-risk population.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available