Journal
BLOOD CANCER JOURNAL
Volume 3, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/bcj.2013.26
Keywords
hematological malignancy; genome sequencing; RNA sequencing; clonal architecture
Categories
Funding
- NIH [CA133115-01]
- Mayo Clinic Cancer Center
- Predolin Foundation
- Mayo Foundation
- [SPORE CA90297052]
- [P01 CA62242]
- [R01 CA83724]
- [ECOG CA 21115T]
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Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis.
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