Journal
BIOMEDICAL OPTICS EXPRESS
Volume 9, Issue 8, Pages -Publisher
Optica Publishing Group
DOI: 10.1364/BOE.9.003923
Keywords
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Funding
- Romanian Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI) [PN-III-P2-2.1-PED-2016-1252, PN-III-P1-1.1-TE-2016-1756]
- University Politehnica of Bucharest, through the Excellence Research Grants Program [UPB-GEX2017] [86/2017]
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Quantitative second harmonic generation microscopy was used to investigate collagen organization in the fibrillar capsules of human benign and malignant thyroid nodules. We demonstrate that the combination of texture analysis and second harmonic generation images of collagen can be used to differentiate between capsules surrounding the thyroid follicular adenoma and papillary carcinoma nodules. Our findings indicate that second harmonic generation microscopy can provide quantitative information about the collagenous capsule surrounding both the thyroid and thyroid nodules. which may complement traditional histopathological examination. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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