Journal
BIOMEDICAL OPTICS EXPRESS
Volume 5, Issue 4, Pages 1050-1061Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.5.001050
Keywords
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Funding
- Smartmix MEMPHIS project the Netherlands Ministry of Economic Affairs
- Netherlands Ministry of Education, Culture and Science
- Gent University-Methusalem project Smart Photonic Chips
- Medical University Vienna
- European Union project FUN OCT (FP7 HEALTH) [201880]
- Bern University of Applied Sciences
- Swiss National Science Foundation [320030_146021]
- FWF-NFN 'Photoacoustic imaging in biology and Medicine'
- Swiss National Science Foundation (SNF) [320030_146021] Funding Source: Swiss National Science Foundation (SNF)
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Optical coherence tomography (OCT) is a noninvasive, threedimensional imaging modality with several medical and industrial applications. Integrated photonics has the potential to enable mass production of OCT devices to significantly reduce size and cost, which can increase its use in established fields as well as enable new applications. Using silicon nitride (Si3N4) and silicon dioxide (SiO2) waveguides, we fabricated an integrated interferometer for spectrometer-based OCT. The integrated photonic circuit consists of four splitters and a 190 mm long reference arm with a foot-print of only 10 x 33 mm(2). It is used as the core of a spectral domain OCT system consisting of a superluminescent diode centered at 1320 nm with 100 nm bandwidth, a spectrometer with 1024 channels, and an x-y scanner. The sensitivity of the system was measured at 0.25 mm depth to be 65 dB with 0.1 mW on the sample. Using the system, we imaged human skin in vivo. With further optimization in design and fabrication technology, Si3N4/SiO2 waveguides have a potential to serve as a platform for passive photonic integrated circuits for OCT. (C) 2014 Optical Society of America
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