Journal
BIOMEDICAL OPTICS EXPRESS
Volume 5, Issue 8, Pages 2837-2842Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.5.002837
Keywords
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Funding
- Ministry for Health, Welfare and Family Affairs, Republic of Korea [HI10C19110300]
- National Research Foundation of Korea (NRF) - Ministry of Education Science and Technology, Republic of Korea [2012R1A2A1A01011328, 2012R1A2A2A01047402]
- National Research Foundation of Korea [2012R1A2A2A01047402] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery. (C)2014 Optical Society of America
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