Journal
BIOMEDICAL OPTICS EXPRESS
Volume 5, Issue 11, Pages 4053-4075Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.5.004053
Keywords
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Funding
- National Institutes of Health [R01-NS060653, NHLBI-HL007915, 8P41-EB015893]
- American Heart Association [14POST20460161]
- Thrasher Pediatric Research Foundation Early Career Award
- Sao Paulo Research Foundation [2012/02500-8, 2013/07559-3]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/02500-8] Funding Source: FAPESP
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We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues. (C) 2014 Optical Society of America
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