Journal
BIOMEDICAL OPTICS EXPRESS
Volume 6, Issue 1, Pages 72-85Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.6.000072
Keywords
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Funding
- NIH [1DP2OD007307-01]
- GIST-Caltech Research Collaboration grant
- Institute of Medical System Engineering at GIST
- Wellcome Trust
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD007307] Funding Source: NIH RePORTER
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Light scattering in biological tissue significantly limits the accessible depth for localized optical interrogation and deep-tissue optical imaging. This challenge can be overcome by exploiting the time-reversal property of optical phase conjugation (OPC) to reverse multiple scattering events or suppress turbidity. However, in living tissue, scatterers are highly movable and the movement can disrupt time-reversal symmetry when there is a latency in the OPC playback. In this paper, we show that the motioninduced degradation of the OPC turbidity-suppression effect through a dynamic scattering medium shares the same decorrelation time constant as that determined from speckle intensity autocorrelation -a popular conventional measure of scatterer movement. We investigated this decorrelation characteristic time through a 1.5-mm-thick dorsal skin flap of a living mouse and found that it ranges from 50 ms to 2.5 s depending on the level of immobilization. This study provides information on relevant time scales for applying OPC to living tissues. (C) 2014 Optical Society of America
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