Journal
BIOMEDICAL OPTICS EXPRESS
Volume 4, Issue 10, Pages 2150-2165Publisher
Optica Publishing Group
DOI: 10.1364/BOE.4.002150
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Funding
- National Institute of Health and National Heart, Blood and Lung Institute Clinical Loan Repayment Program
- Columbia University
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Abnormal changes in orientation of myofibers are associated with various cardiac diseases such as arrhythmia, irregular contraction, and cardiomyopathy. To extract fiber information, we present a method of quantifying fiber orientation and reconstructing three-dimensional tractography of myofibers using optical coherence tomography (OCT). A gradient based algorithm was developed to quantify fiber orientation in three dimensions and particle filtering technique was employed to track myofibers. Prior to image processing, three-dimensional image data set were acquired from all cardiac chambers and ventricular septum of swine hearts using OCT system without optical clearing. The algorithm was validated through rotation test and comparison with manual measurements. The experimental results demonstrate that we are able to visualize threedimensional fiber tractography in myocardium tissues. (C) 2013 Optical Society of America
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